Baló-like Lesion With Psoriasis and Autoimmune Thyroiditis

Bal-like Lesion With Psoriasis and Autoimmune ThyroiditisBAL-LIKE LESION ASSOCIATED WITH PSORIASIS AND CHRONIC AUTOIMMUNE THYROIDITISAuthorsCorina Roman-Filip1, Aurelian Ungureanu2, Ileana Prvariu3AbstractVariants of multiple sclerosis are seldom encountered in clinical practice, sometimes with reserved prognosis or possibly serious disability. These pathologies are characterized by atypical demyelinating lesions such as Bal-type lesions or tumefactive lesions. The mechanism do-nothing these lesions still remains a debate, since genetic and immune factors are incriminated. We present a case of multiple sclerosis variant with remarkably good consequent in association with autoimmune thyroiditis and psoriasis. This concomitant process questions the possibility of shared immune pathogenesis regarding the activation of T helper 17 cells lineage and mitochondrial oxidative stress. The imagistic show of the found lesions raises discussions on a possible radiologic diagnosis.Keywords Bal -type lesions tumefactive lesions psoriasis autoimmune thyroiditis T helper 17 cellsIntroductionPathologist Jzsef Bal expound a particular bring of demyelinating disease, leukoencephalitis periaxialis concentrica, classically named Bals concentric sclerosis (BCS). Nowadays, this is defined as a variant of multiple sclerosis. The intensive use of magnetic resonance showed an increasing total of different types of demyelinating lesions. Some of these are specific, but a large variety is under debate regarding the classification. Tumefactive demyelinating lesions (pseudotumoral) fuck sometimes present a degree of concentricity and can be easily mistaken for a genuine Bal lesion, or at least a Bal-like demyelinating lesion. Historically, the variants of multiple sclerosis were regarded as serious disabling insurgent damages of the central nervous system, but recent works have demonstrated that the course of the disease may be more variable, at least regarding BCS. Imagistic studies can lead to a better appreciation on the prognosis of BCS and its association with other types of demyelinating lesions 1. The pathological mechanism behind it still remains a debate, although one can find similarities with multiple sclerosis (MS) and even overlapping lesions of these conditions.Case reportWe present the case of a 40-year-old woman admitted for mild incoordination of the left(a) arm and speech impairment. The patients medical history is positive for psoriasis (since 2002) and autoimmune thyroiditis under treatment with levothyroxine 50 ug/day (since 2010). Magnetic resonance imagery (MRI) studies revealed FLAIR and T2 weight inhomogeneous hyperintense lesions with concentric enhanced and non-enhanced lesions on T1 with gadolinium contrast (fig 1ab). The lesion was characterized as atypical demyelinating with 22.5/21.6 mm in size, with late concentric sweetener and without mass effect. Additionally, two demyelinating periventricular enhancing lesions were found ( fig 1def). A biochemistry panel, antinuclear antibodies, anti-ds DNA antibodies, ANCA antibodies, anti Ro antibodies and anti-Borrelia antibodies were negative. Slight pleocytosis (16 cells/mm3 with 75% monocytes) was detected in the cerebrospinal fluid together with present oligoclonal bands and regular proteins. Serum myelin oligodendrocyte glycoprotein antibodies, myelin basic protein antibodies, IgG anti-aquaporin 4 antibodies were negative. Moreover, a high serum titre of anti-thyroperoxidase antibodies (60.73 IU/mL normalDiscussionThe association of the pathologies described may seem omissible. However, strong research evidence shows the implication of Thelper17 cells (Th17) and Interleukin 17 (Il17) in the autoimmune pathways of MS, autoimmune endocrinopathy and psoriasis 2,3. BCS type lesions and MS lesions may both be present simultaneously in the same patient, and Bal-like lesions may change over time into the classic appearance of MS lesions 4. The lesions are characte ristic, with rings of demyelination, surrounded by partial demyelinated regions, reflecting the concentricity within the lesion. The lesion type is classified as MS pattern III with oligodendrocyte loss, microglial activation and loss of myelin-associated glycoprotein 4. Studies of 7 Tesla MRI support the microvascular pathology associated to inflammation, which seems to be consonant with pattern III lesions 5. These studies are sustained by identifying Notch 3 mutation in a patient with BCS phenotype and a family history of Notch 3 mutation carriers and CADASIL. Mitochondrial respiratory chain disturbance and the expression of some molecules probably tend to precondition hypoxic tissue to inflammation, such as mitochondrial heat shock protein 70 6. Furthermore, new cellular biology studies of cancer found that hsp70 can mediate the Th17 differentiation 1. We consider that the simultaneity with the autoimmune endocrinopathy and psoriasis may be more than incidental and raises the h ypothesis of probable linkage of the proinflammatory and autoimmune role of Th17 cells lineage with mitochondrial oxidative stress.Compliance with Ethical StandardsConflict of Interest The authors declare that they have no conflict of interestInformed consent was obtained from all individual participants included in the studyFig. 1 a. T1 gadolinium sequence showing a frontlet demyelinating lesion with concentric enhancing rings (arrow) b. T2 weighted image with concentric rings of demyelination and myelinated regions (arrow) c. DWI sequence with diffusion restriction in the active lesion d. T1 gadolinium enhancement of periventricular lesion (arrowhead) e. Enhancing periventricular lesion in the occipital lobe (arrowhead) f. Coronal T2 small demyelinating lesion (arrowhead) with enhancement on T1 (not shown)Fig. 2 a. T1 gadolinium sequence showing a significant improvement six months later (arrow) b. T2 weighted image showing the demyelinating lesion markedly decreased (arrow) c. D WI d, e, f. Improvement of demyelinating lesionsReferencesHardy TA,Miller DH (2014) Bals concentric sclerosis. 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